A Clinical Study of the Warthin's Tumor of the Salivary Gland / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: The aim of this study was to define the clinical characteristics and treatment outcome of the salivary Warthin's tumor in order to work out a therapeutic strategy. SUBJECTS AND METHOD: The medical records of 64 patients who underwent surgery and were pathologically diagnosed with Warthin's tumor at our department from January 1997 to December 2009 were reviewed retrospectively. RESULTS: There were 60 (94%) males and 4 (6%) females with an overall male-to-female ratio of 15 : 1. The average age was 59.8+/-9.2 years (range from 35 to 78). All tumors were found in the parotid gland. Of the 66 tumors, 31 (48%) occurred in the right side, 28 (44%) tumors occurred in left side, and 5 (8%) tumors occurred in bilaterally. A superficial parotidectomy was performed in 38 (59%) patients, lumpectomy in 25 (39%) patients and bilateral lumpectomy in one patient. There were 18 (28%) postoperative complications. The most common complication was transient facial palsy that occurred in 11 (17%) patients. Recurrence occurred in 2 (3%) patients, oneipsilaterally and the other contralaterally. All recurrences were found in patients who underwent superficial parotidectomy. CONCLUSION: Warthin's tumor has a very low recurrence rate with a benign nature. The study shows that lumpectomy is an effective surgical treatment for Warthin's tumor with an advantage of reducing facial nerve palsy and recurrence rate.

The Analysis of Induction Chemotherapy Using Docetaxel and Platinum in Treatment of Hypopharyngeal Carcinoma / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: The aim of this study was to determine the efficacy of induction chemotherapy with docetaxel and platinum in patients with hypopharyngeal carcinoma. SUBJECTS AND METHOD: The medical records of 66 patients who were diagnosed with hypopharyngeal carcinoma at our department from January 1996 to December 2008 were reviewed and retrospectively analyzed. The patients were divided into four groups according to treatment method: Group I was treated with radiation and induction chemotherapy consist of docetaxel and platinum (27); Group II was treated with surgery and induction chemotherapy consist of docetaxel and platinum (28), Group III was treated with radiation and induction chemotherapy consist of 5-FU and platinum (9) and Group IV was treated with surgery and induction chemotherapy consist of 5-FU and platinum (2). A total of 186 chemotherapy cycles were administered to patients and most of the patients received at least 2 cycles. RESULTS: The T-stage distribution at diagnosis was 7.5%, 42.4%, 28.8%, and 21.2% for T1, T2, T3, and T4, respectively. The N-stage distribution at diagnosis was 48.5%, 22.7%, 10.6%, 15.2%, and 9.1% for N0, N1, N2a, N2b, and N2c, respectively. The overall 3-year survival rate was 44.3%. The 3-year survival rate of each group was 42.6% in Group I, 54.8% in Group II, and 11.1% in Group III. There was no significant difference in survival between Groups I and III (p=0.074). There was no difference in sex, age, and N stage for 3-year survival rate. CONCLUSION: Although any valid conclusions could not be drawn because of the small number of patients examined here, induction chemotherapy consisting of docetaxel and platinum may improve the outcome of patients with hypopharyngeal carcinoma.